Solutions
Chemical synthesis cannot keep pace with RNA innovation. Our proprietary ezRNA™ platform builds RNA enzymatically and promises long-term manufacturing solutions to sustainably deliver RNA therapeutics at scale.
-
01
Capabilities
01 | Capabilities
Our ezRNA™ platform is flexible and expansive. Solutions range from complete de novo RNA synthesis to single extensions off therapeutic payloads, while accessing enhancements such as site-specific modifications, fluorophores, and clickable handles.
-
02
Modifications
02 | Modifications
Our ezRNA™ platform has the proven capability to incorporate a diverse array of nucleotide modifications – critical for RNA therapeutic viability – including modifications at the sugar, backbone, and base. The platform can provide access to novel modifications that current production methods fails to deliver.
-
03
Sustainability
03 | Sustainability
Our ezRNA™ platform enables template-independent synthesis in aqueous-based reaction conditions. This advancement fundamentally eliminates regulated organic solvents and provides better atom economy for sustainable solutions at scale.
Our enzymatic synthesis platform unlocks site-specific and diverse RNA modifications
-
01Base
Base
Standard and non-standard nucleobases can be incorporated with the ezRNA™ platform. Additional modifications to these nucleobases are also supported
-
02Backbone
Backbone
The ezRNA™ platform can install both standard and phosphorothioated backbones
-
032’- Modifications
2’- Modifications
Essential for siRNA therapeutics, EnPlusOne can incorporate all standard toolbelt 2’- modifications and has pushed into novel mods.
-
043’- Modifications
3’- Modifications
The flexibility of the platform also provides access to 3’- modifications including linkers and chain terminators.
